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KN-92 phosphate

CAS No. 1135280-28-2

KN-92 phosphate( —— )

Catalog No. M17153 CAS No. 1135280-28-2

KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KN-92 phosphate
  • Note
    Research use only, not for human use.
  • Brief Description
    KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII).
  • Description
    KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
  • In Vitro
    KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50μM; 24 hours) is ineffective in blocking cell growth.The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21. Cell Viability Assay Cell Line:Human hepatic stellate cells (LX-2) Concentration:5-50 μM Incubation Time:24 hours Result:Ineffective in blocking cell growth.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CaMK
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    1135280-28-2
  • Formula Weight
    554.98
  • Molecular Formula
    C24H28ClN2O7PS
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : < 0.1 mg/mL
  • SMILES
    OP(O)(O)=O.COc1ccc(cc1)S(=O)(=O)Nc1ccccc1CN(C)C\C=C\c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rokhlin OW, Guseva NV, Taghiyev AF et al. Cancer Biol Ther. 2010 Feb;9(3):224-35.
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